Hungover? This Juice Will Help

https://youtu.be/vueXVaJMldo   Doctor Nick Delgado, and I'm here with Doctor Barry Sears ,the author the Mediterranean Zone: Unleash The Power The World's Healthiest Diet. It's great to see again! The last time we were together might have been 2006 in Japan. Yes. In the gym. The only two English-speaking individuals. You know, you're doing some interesting work. You were one of the early pioneers in drug delivery systems, Specifically dealing with those areas that target inflammation. What you then spun off and started working in your own area and arena and trying to educate people. But they weren't listening were they? Well, even they weren't listening or I wasn't giving a very good story. Okay, the story is very complex, the story is very delicate Yeah and so it's like a political campaign with the breakdown in sound bites for people understandable both at the medical research level and at the level of the individual patient. So again a lot of that is busy honing the story having the dealer becoming the bear supporting the story. And so as we've now well into the 21st century I can see very clearly that my insight forty years ago was probably right. Whoever controls information controls the future of medicine. Now will it be the drug companies or will it be the food we eat? I'm putting my bet on the food we eat. Well you made a good point. Our bodies and our genetics in our DNA have become accustomed to nutrients during the entire evolution of all humans. And now we're trying to target certain drugs that are isolates of those same very important nutrients. Well, and this is you know drugs do have an important role to play. They tell us what are the gene transcription factors that turn our genes on and off. They say thank you, you've done your job now. Now our job is to find out which new treatment, diet, does the same job and at what level. One of the problems with nutrient as opposed to drugs is that oftentimes we use nutrients at placebo levels. When you use placebo levels, you get placebo results. So we had to find what's the gene factor we are looking to alter and what is the therapeutic dose of that nutrient to make it happen. Doctor Barry Sears, is it fair to say that cancer, heart disease, stroke, diabetes, arthritis, all have some direct or indirect relationship to inflammation? No question, no question. And that's why we make medicine often times more complex and will use we try to basically sub-sect into very say different cancers, heart disease. These are all different manifestations of inflammation. With cancer we have inflammation of the immune system. With heart disease we have inflammation of the heart, alzheimer's is inflammation of the brain. So basically now we're seeing inflammation move like metastasis in cancer, through different parts the body. So what is the solution? You've come up with some novel ideas identifying some of the very nutrients in plant foods and we've seen a change in the human diet. I mean what we're eating far differently than we did maybe our ancestors. -Well, we're eating far differently than even our grandparents. Yeah, it's a very rapid change because the globalization a food technology. I call it food technology That is we can now make food incredibly cheaply. We can make it very tasty But there's been a lot of collateral damage- increased inflammation and now a trio of diseases which are consequences the obesity the diabetes the heart disease so we can basically look to the internet for what I call Food Technology 2.0- not using food to make you fat and sick, but food to be help understand how we interact with gene transcription factors that make you lean and maintain wellness. So it ushers in a whole new era of food but food is grown.- So Doctors Sears, is it possible we can through epigenetics, alter the expression of those genes with some other technology you're talking about? No question. But the fact is the whole aspect of epigenetics change our understanding of quote the genome. We thought it was so simple. Once we transcribed the genome we know how to cure disease that was a very very bold statement that's not fair. Naive, too. Totally naive. Because we now know is the epigenetics, and this is how our diet how we interact with stress, toxins are fromed, how they can altered expression or genes, and now we find the complexity. But becomes good news because we can use things in our environment, our diet particularly, to avoid toxins. To basically now change the epigenetic marks that we often have left behind that are causing great havoc to our health care system So Dr. Sears, people are exposed to PCB's Zeno estrogens, pesticides that have an estrogen base We're becoming a society dominated by extractions and they're by product chemicals. Now we're becoming genetically modified We all complain about GMO's. Hey, you're fighting the wrong battle here We're becoming genetically modified because now we know that many these toxins, and also ingredients in our diet complete great havoc to genome programming to basically change not only the expression of genes in the in the trial but now it's trends generation These epigenetic marks can last up tothree generations and that's what we're seeing play out right now. In America we are the fastest growing group of obese individuals ages 0-2. Consequently what do they do? They are no a consequence of this ongoing amplification of inflammatory genes. That started not the last generation, but with several generations ahead. So we have we force a multi generation task to bring our genome back to safety. Dr. Sears, what is the importance of diagnostic testing? What can we learn from novel new advancements in the testing technology arena? Well, its the same we can learn from business. You can't you know manage would you can't measure. So we don't measure things because how could we manage them? Unfortunately most of our management are dealing in terms of markers a disease. We have very few markers of wellness. Our goal is not to treat the symptoms of chronic disease but to maintain wellness. So one of the best markers of looking at wellness is ratio of fatty acids in your blood. One is called arachidonic acid, this is an omega 6 fatty acid. It is a building block of very powerful proinflammatory hormones. The other is the omega 3 fatty acid ecasa pentanoic acid, the building block of equally powerful anti-inflammatory hormones. You need both to keep them balanced. That's my molecular definition of wellness. When inflammation is counterbalanced by resolution you bring the body back to equilibrium. What we have now is a mismatch. A mismatch of these two very powerful forces where we are now in a constant state of low-level, chronic inflammation. Which the driver for all the chronic disease that we complain about in our health care system. So that test, which is a standard test, not standard in that you go to a company like quest, but standard at Harvard Medical School and that will tell your future. If you don't like a future, you can change it within 30 days. But that if he took only one blood test that be the most important. It tells you really the balance of inflammation and resolution in your body. There are other blood tests, like the ratio triglycerides to HDL indicates the spread a bit on the system's premier fat cells to look.Another one, glucosamine a marker long-term glycemic control these three markers give you an indication of how well you are. And that's the goal of the doctors now in the 21st century. To keep you as well as possible as opposed to saying we will treat the symptoms of chronic disease after it manifests. - So omega 3,6,9, I think the general public gets a little confused and also the goal of a certain ratio: 2 to 1 What do you like to see? Help the audience understand a little more about that.- Well again remember we have to balance inflammation and resolution. And the inflammation comes from omega 6 fatty acids, in particular, arachidonic acid Resolution comes from omega 3 fatty acids particularly EPA. So I like to keep it about the ratio of those two in the blood about 1.5. So I have a little more omega 6 fatty acids in the diet than omega 3's. Okay, that means a ratio of or is fine. What's the ratio on the market today? It's about -Wow!- And that's why we look at the ratio arachidonic acid and EPA in Americans it's about 18. In Japanese the longest lived people in the world, people have the longest health span. That's longevity minus years of disability. Their ratio is 1.5- 10 times lower So that's why we have such the chronic health care problems America We're the most inflamed people on the face of the earth .